| Brand name | ActiTide-AH3 |
| CAS No. | 616204-22-9 |
| INCI Name | Acetyl Hexapeptide-3 |
| Chemical Structure |  |
| Application | Lotion, serums, mask, facial cleanser |
| Package | 1kg net per bottle /20kgs net per drum |
| Appearance | Liquid/Powder |
| Acetyl hexapeptide-3(8) (Liquid) | 450-550ppm 900-1200ppm |
| Purity (Powder) | 95% min |
| Solubility | Water soluble |
| Function | Peptide series |
| Shelf life | 2 years |
| Storage | Store in cool and dry place, away from light. 2~8℃ for storage. |
| Dosage | 2000-5000ppm |
Application
The anti wrinkle hexapeptide ActiTide-AH3 represents the discovery of a positive hit based on a scientific pathway from rational design to GMP production. The study of the basic biochemical mechanisms of anti-wrinkle activity has led to this revolutionary hexapeptide which has taken the cosmetic world by storm.
Finally, a wrinkle treatment which can compete with the efficiacy of Botulinum Toxin A but leaves aside the risks, the injections and the high cost: ActiTide-AH3.
Cosmetic benefits:
ActiTide-AH3 reduces the depth of the wrinkles caused by the contraction of the muscles of facial expression, especially in the forehead and around the eyes.
How does ActiTide-AH3 work?
Muscles are contracted when they receive neurotransmitter that travels within a vesicle. The SNARE (SNAp RE ceptor) complex is essential for this neurotransmitter release at the synapsis (A. Ferrer Montiel et al, The Journal of Biological Chemistry, 1997, 272, 2634-2638). It is a ternary complex formed by the proteins VAMP, Syntaxin and SNAP-25. This complex is like a cellular hook which captures vesicles and fuses them with the membrane for the release of neurotransmitter.
ActiTide-AH3 is a mimic of the N-terminal end of SNAP-25 which competes with SNAP-25 for a position in the SNARE complex, thereby modulating its formation. If the SNARE complex is slightly destabilized, the vesicle can not dock and release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.
ActiTide-AH3 is a safer, cheaper, and milder alternative to Botulinum Toxin, topically targetting the same wrinkle formation mechanism in a very different way.
